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Samuel J Klempner

Samuel J Klempner, MD

Medical OncologyHematology

Highlights

Age Groups Seen

  • Adults
  • Geriatrics

Languages

  • Spanish
  • English

Gender

Male

About Samuel J Klempner

Dr. Klempner completed his residency in internal medicine at Brigham and Women’s Hospital/Harvard Medical School, followed by a combined hematology-oncology fellowship at Beth Israel Deaconess Medical Center/Harvard Medical School. While at Harvard Dr. Klempner studied the mechanisms of resistance to targeted therapies in tumor cells in the lab of Dr. Lewis Cantley, PhD. Dr. Klempner is board certified in medical oncology, hematology, and internal medicine, and belongs to several oncology research societies including the American Society of Clinical Oncology (ASCO), European Society of Medical Oncology (ESMO), the American Association for Cancer Research (AACR). His work has been published in multiple journals including Journal of Clinical Oncology (JCO), Cancer Discovery, Lancet Oncology, JAMA Oncology, Annals of Oncology and others. He is an active member of the ASCO TAPUR trial molecular tumor board and serves on the editorial board of JCO Precision oncology.

As a member of the gastrointestinal cancer group at MGH Dr. Klempner works in a multidisciplinary team to optimize and individualize treatment using molecular characterization across all stages of GI cancers. He conducts clinical trials and translational research with new targeted agents and immune therapies, and is active in the gastroesophageal cancer community where he serves on the advisory board of Debbie's Dream Foundation and Hope for Stomach Cancer. He has received several awards for his care of patients with GI cancers. Originally from Wayland, MA he is an avid Boston sports fan.

Locations

  1. Mass General Brigham Cancer Institute Medical Oncology at the Tucker Gosnell Center for Gastrointestinal Cancer
    • 32 Fruit Street, Yawkey Building, 7th Floor, Suite 7e, Boston, MA 02114
    • Get Directions

Expertise

Education

  • Fellowship: Beth Israel Deaconess Hospital, Hematology & Oncology, 2013
  • Residency: Brigham and Women's Hospital, Internal Medicine, 2010
  • Medical Education: University of Massachusetts Medical School, 2007

Board Certifications

  • Internal Medicine: American Board of Internal Medicine, 2013

Insurance

This provider may accept more insurance plans than shown. Please call the practice to find out if your plan is accepted.
Search plans
  • Aetna
  • Beech Street
  • Blue Cross Blue Shield
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield Medicare
  • Cigna
  • Commonwealth Care Alliance
  • Coventry
  • Fallon Health
  • Harvard Pilgrim Health Care
  • Humana
  • Maine Community Health Options
  • Mass General Brigham Health Plan
  • MassHealth
  • Medicaid CT
  • Medicaid ME
  • Medicaid NH
  • Medicaid RI
  • Medicare
  • Medicare ACO
  • Multiplan
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Tufts Medicare Preferred
  • United Health Care
  • Wellpoint
  • WellSense
  • WellSense NH

Ratings & Reviews

5 out of 5

104 ratings, 48 reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

How likely would you be to recommend this provider to your family and friends?
Search reviews
  • Reviewed on 3/3/2026

    Excellent

  • Reviewed on 2/26/2026

    Excellent care by everyone involved

  • Reviewed on 2/24/2026

    mostly fine

  • Reviewed on 2/26/2026

    Very good.

  • Reviewed on 2/20/2026

    Dr. Klempner is one of the best doctors I've had in my [redacted] years (and I've seen a lot of doctors!). I know he has an enormous case load, but he treats me like I'm the only one, he's focused, direct, and kind. I know I'm in the very best hands with his care! (My literally life depends on him). Can't say enough positives about him and MGH!

  • Reviewed on 2/17/2026

    I am fortunate to have Dr. Klempner and my entire oncology team at MGH. The best!

  • Reviewed on 2/17/2026

    Dr. Klempner and his team went over and above to explain in detail what we, my advocate and myself were to expect through all the upcoming cycles, as well as the processes from start to finish. He/they did and especially great job addressing our concerns about the sensitive areas of the treatments as well as broke down the complicated medical jargon and complicated process of drug administration. Dr. Klempner reassured us, made us feel informed and comfortable!

  • Reviewed on 2/16/2026

    My first 4 years of cancer treatment was in NJ. My last year was in the care of Dr. Klempner due to our move to Mass. I was impressed with Dr. Klempner's professional manner, his wonderful communication skills and his genuine concern for my well-being.

  • Reviewed on 2/27/2026

    The Dr listened patiently to my concerns & gave suggestions regarding my questions.

  • Reviewed on 2/26/2026

    Dr. Klempner was extremely professional and walked into the appointment with past knowledge of her medical history. He explained everything thoroughly and in a way that is easy to understand. It was super helpful that he walked us through my mom's recent CT scan and the options she has based on her type of cancer. I only wish we were located in Boston to receive primary care for her.

  • Reviewed on 1/21/2026

    Dr Sam Klempner is an outstanding oncologist. He is extremely thorough and explains the phases of my cancer and options available. I am so grateful for is medical advice as well as the support through this process. I'm fortunate to call him my doctor.

  • Reviewed on 12/25/2025

    The doctor was professional and caring.

  • Reviewed on 12/24/2025

    The best I've ever experienced in terms of familiarity with my case, expertise in his field, clear communication, and empathy.

  • Reviewed on 12/15/2025

    I have nothing but the highest praise for Dr.Klempner and his team I have received nothing less than exceptional care from them.

  • Reviewed on 12/15/2025

    Dr Klempner is the absolute best oncologist!!!

  • Reviewed on 12/9/2025

    I have been seeing Sam for almost 2 years. There aren't enough superlatives to describe him. He is, no doubt, one of the finest Doctors I have ever dealt with in my [redacted] years on this planet!

  • Reviewed on 11/26/2025

    Dr Klempner has always been available to me when and if I have concerns regarding my treatment.

  • Reviewed on 11/21/2025

    Dr. Klempner is the best in every way! Amazing dedication to his field of expertise!

  • Reviewed on 11/12/2025

    Excellent

  • Reviewed on 11/2/2025

    Knowledgeable and took the time to explain and listen.

  • Reviewed on 10/19/2025

    It was a hood experience, no complaints.

  • Reviewed on 10/19/2025

    He completely broke my options down in an easily understandable way. He had an incredibly kind and down to earth manner during our visit. I look forward to being under his care for this cancer journey

  • Reviewed on 10/19/2025

    Sam Klempner is outstanding. He explained things to us in an exceptional way and this made me feel like the providers at MGH oncology are determined to help me and their other patients. He has a calming presence and this made me feel safe. Truly, I cannot say enough positive things about him.

  • Reviewed on 10/15/2025

    I am pleased he will be taking care of me.

  • Reviewed on 10/9/2025

    Dr. Klempner has great technical and coordination skills. His office communicates very well with my other MGH caregivers and coordinates his treatment of me with others on my cancer treatment team.

  • Reviewed on 9/21/2025

    I've been seeing Dr. Klintner for almost five years. He actually saved my life. We get along real well. He's very thorough in his explanation of his treatments, and he's very responsible. He's very accurate, and he's very, He's a heartwarming person. He's easy to talk to, easy to get along with, and he's an excellent doctor. He's probably one of the better doctors at Mass General Hospital. I appreciate everything he's done for me. That's all I have to say. Thank you.

  • Reviewed on 9/4/2025

    He was AWESOME! Kind, professional, compassionate!

  • Reviewed on 8/22/2025

    Yes, Dr. Klempner was amazing. He spent a good hour with us going through all kinds of information and answering any question we had. And we did not get that from our last provider at Sloan. He was just amazing. And I'm thankful that we were sent to him.

  • Reviewed on 8/12/2025

    Everyone was professional and courteous. They explained everything in a way that I could understand.

  • Reviewed on 8/6/2025

    This provider is exceptional in his ability to explain test results as well as medical plan going forward....very thoughtful and understanding

  • Reviewed on 7/27/2025

    My care people are the best .

  • Reviewed on 7/14/2025

    Both Dr Klempner and Dr [redacted] have always made me feel like I was their only patient. Undivided attention. They are both easy to talk to as well as easy to listen to. A+ team!

  • Reviewed on 7/1/2025

    Dr. Klempner excels in his social role: He is timely, patient, earnest, and above all, exceedingly intelligent, showing he has absorbed your physical and emotional needs after the first meeting and for us, that was mask time 4 &1/2 years ago. Our cancer is stubborn, but so are we. He has said he has many cancer-fighting tools in his arsenal. His knowledge is his most potent tool.

  • Reviewed on 7/3/2025

    I had a good experience with the doctor and he took the time to answer all my questions and didn't feel rushed. I felt like he'd give me as much time as I needed.

  • Reviewed on 6/30/2025

    I need a new doctor.

  • Reviewed on 6/25/2025

    He was caring and explained thing in a way which was easy to understand.

  • Reviewed on 6/25/2025

    Fantastic experience. Very happy to be with this team!

  • Reviewed on 6/18/2025

    Dr Klempner has been exceptional providing my treatment for the past five years. I am now cancer free due to the treatment he provided. I would not hesitate to recommend him and Dr [redacted]

  • Reviewed on 6/16/2025

    It is a long drive but well worth it

  • Reviewed on 6/11/2025

    Dr Klempner is an exceptional oncologist. We couldn't be happier with what he is doing to help me through this difficult struggle...

  • Reviewed on 6/1/2025

    I felt respected and that he really cared about me and spoke to me and my wife in terms that we understood

  • Reviewed on 5/29/2025

    Dr. Klempner is top-notch, one of a kind. He's the reason why he was sought out by me to help me with this reoccurrence of cancer. His bedside manner, one of a kind. His Harvard education and background and his willingness and ability to continue to study and seek breakthroughs within the oncology atmosphere is unprecedented and just very unique in its own ways. I just enjoy his bedside manner, his expertise, and Mass General is a very opportuned to have him. He's a great person.

  • Reviewed on 5/26/2025

    The way they give me a hope was amazing.

  • Reviewed on 5/10/2025

    This doctor is great- so knowledgeable, kind , caring and patient.

  • Reviewed on 5/8/2025

    Dr. Klempner is the best. I've never seen a doctor like him. I just can't say enough about him. [redacted] he's fantastic. I just can't, like I said, say enough about him and his whole team.

  • Reviewed on 5/7/2025

    Dr. Klempner is an incredible doctor. He presents his findings in a calm measured manner instilling confidence that the situation while serious is manageable and with specified steps can get me back to the quality of life I am looking for. He then outlined the steps and where we go from there.

  • Reviewed on 5/8/2025

    Dr. Klempner is the best. He was amazing. He analyzed the problem right at the beginning, diagnosed what type of cancer I had and what the genetic makeup of it was, and attacked it with the exact therapy that it needed. I couldn't have asked for a better result. It was very scientific but explained very simply. He is amazing. Thank you.

  • Reviewed on 5/2/2025

    The doctor and the staff have always been very professional, very polite, and extremely courteous. I would highly recommend Dr. Sam Klempner and his team 100% of the time. Thank you.